natural healing
While the Fountain of Youth may be a legend, the closest we can get now lies in another powerful fluid: our blood. Advanced platelet-rich fibrin (PRF) technology further refines the process to create a potent natural injectable. Less cell damage means PRF EZ Gel contains around ten times the amount of healing platelets naturally found in the body.
At Refine Anti-Aging Medicine and Aesthetics, we are passionate about delivering the most innovative anti-aging treatment options for our patients. PRF Bio Filler, or PRF ezGel, is the next generation of PRF age-defying strategies, and we deliver the best PRF EZ Gel Oakland has to offer.
What is PRF? PRF vs PRP PRF EZ Gel Benefits Ideal Candidates
Platelet-rich fibrin (PRF) is a blood plasma by-product that is 100 percent natural and contains no additives or chemicals, earning it the nickname “the ultimate blood concentrate”. This unique concentration, rich in stem cells, platelets, white blood cells, and long-lasting growth factors, accelerates healing and encourages the body’s natural repair abilities.
How is Platelet-Rich Fibrin Harvested?
During treatment, a small amount of blood is taken, spun in a centrifuge, and then growth-factor-rich platelets are injected into the treatment area.




The first difference between PRF and PRP is the processing technique. PRP is spun in the centrifuge at a very high speed which separates the blood plasma layer completely. In contrast, due to a slower spin rate, some stem cells, white blood cells, and fibrin are retained in the platelet layer with PRF.
In addition, no anticoagulants or additives of any kind are used in PRF. This results in the presence of a fibrin matrix that allows the platelets to release growth factors at a slower rate for more sustained, gradual, and thus longer-lasting results. PRP releases its growth factors quickly because the anticoagulants prevent this fibrin matrix. Finally, the way these treatments are used is slightly different. While PRP is effective for less severe lines and wrinkles, it is not ideal for deep lines or hollow areas. PRF Gel can address the same concerns as PRP along with more severe signs of aging, including lack of volume as a bio-filler.
PRF EZ Gel is known as a bio-filler because it can achieve similar results to synthetic fillers while using 100% natural substances derived from your own blood. After the centrifuge spin, your blood is then cooled and heated in a precise process with no chemicals or other additives and injected into the treatment area just like a dermal filler. Because of its unique consistency, the growth factors and platelets found in PRF EZ Gel are released gradually over weeks versus days with PRF liquid and hours with PRP.
PRF EZ Gel is a highly safe and effective rejuvenation option for aging or dull skin. With EZ Gel, we can treat undereye smile lines, cheeks, temples, and Marionettes to improve skin quality and stimulate collagen. Benefits include:

Platelet-rich fibrin (PRF) is an effective treatment for the under-eye area as it increases collagen firming the skin and giving the eyes a refreshed and youthful appearance.
The result is under-eye rejuvenation, improving dark circles, hollowing, and under-eye puffiness.
PRF is recommended for under eye treatment if you have:

This treatment is naturally made and non-surgical, so many patients who are seeking to address signs of facial aging are candidates.
Most of our Oakland PRF patients want to address under the eyes or tear troughs, cheek volume, marionette lines, nasolabial folds, lip lines, or other significant aging concerns.
Our goal at a consultation is to ensure that each patient receives a tailored treatment plan that meets their exact needs. If we determine that PRF treatment is ideal for you, we will discuss preparation, maintenance, and expectations for results. We usually recommend an initial treatment plan of two to three treatments about six to eight weeks apart.
There is no downtime needed after PRF treatment, but you may experience some redness or tenderness. Typically, optimal results are noticeable within two to three weeks and gradually develop over a few months, lasting up to a year.
We make it easy for you to learn more about the great things PRF ez Gel can do for you. Call us at (510) 462-2662, text us at (510) 462-2662, or fill out the appointment form on our website!
Most of our Oakland PRF EZ Gel patients experience only mild discomfort, if any, and report that the process is very tolerable.
The PRF EZ Gel system is very safe, and the gel is made only with components from your own body—no additives. Possible minor side effects could include bruising, swelling, or redness.
While these treatments are not permanent, most patients retain great results for about six to twelve months. For optimal, lasting results, we typically recommend follow-up treatments one to two times a year.
The cost of PRF EZ Gel treatment will depend on the extent of the treatment and where it will be used.